Effect of supplement jelly intake basic treatment of periodontal disease: randomized placebo controlled study. (ESTOP Study)

INTERVENTION: Supplement jelly group Take supplement jelly in one bag of once a day between after supper and before bedtime. Placebo jelly group Take placebo jelly in one bag of once a day between after supper and before bedtime. CONDITION: Periodontal diseases (intrabony defect with probing depths more than 4mm) PRIMARY OUTCOME: Probing pocket depth (PD); Bleeding on probing (BOP) INCLUSION CRITERIA: 1)Patients having probing depths more than 4mm. 2)The day of agreement for this study is 20 years or older (gender‐free). 3)All patients gave written informed consent.