Contrast-enhanced vs. B-mode Ultrasound-guided Percutaneous Biopsy of Retroperitoneal Tumors

Background: Retroperitoneal tumors are typically large and inhomogeneous, with a variable amount of necrosis within the tumor mass which decreases the diagnostic yield of biopsy (false negative or inadequate). Rationale: Real‐time contrast enhancement can highlight the viable tumoral tissue and avoid the necrotic area. Aims: To compare contrast‐enhanced ultrasound (CEUS) guidance and conventional (B‐mode) ultrasound (US) guidance in terms of diagnostic yield, need for repeat biopsy, and rate of adverse events. Methods: A consecutive series of patients with previously documented retroperitoneal tumors and indications for percutaneous biopsy were randomly assigned to benefit from the standard of practice B‐mode US‐guided biopsy or CEUS‐guided biopsy. The diagnostic accuracy, need for repeat biopsy, and adverse events were noted.