A clinical research based on multi-fMRI of acupuncture combined with SSRIs treating major depressive disorder

INTERVENTION: sham acupuncture+SSRIs:sham acupuncture;acupuncture+SSRIs:Acupuncture; CONDITION: Major Depression Disorder PRIMARY OUTCOME: HAMD24; SECONDARY OUTCOME: VAS;HAMA;PSQI;SERS; INCLUSION CRITERIA: 1) Patients who meet the diagnostic criteria for depression in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM‐5), published by The American Psychological Association (APA) in 2013. 2) Between the ages of 18 and 65 years, regardless of gender 3) Score of >20 on the 24‐item Hamilton Depression Inventory (HAMD24) and score of =2 on HAMD24 item 1 (depressed mood) 4) Clinical General Impression Inventory‐Severity of Illness (CGI‐S) score = 4 5) Right‐handedness. 6) The patient understands and voluntarily accepts the treatment and signs an informed consent form.