Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring

This study evaluates whether a non‐invasive brain stimulation technique called TemporalInterference (TI) can reduce epilepsy‐related abnormal brain activity and influencesleep‐related brain rhythms in adults with focal drug‐resistant epilepsy undergoingstereo‐EEG monitoring for clinical care. Up to 30 participants will complete stimulationsessions during wakefulness and, when possible, natural non‐REM sleep. Brain activitywill be recorded using scalp EEG and implanted sEEG electrodes before, during, and afterTI stimulation. Some participants may also receive subthreshold direct stimulationthrough implanted electrodes for comparison. The study aims to determine whether TI canreduce epilepsy biomarkers, alter sleep‐related brain activity, and compare favorablywith conventional direct electrical stimulation while remaining within established safetylimits.