Study on the clinical efficacy and distribution pattern of sensitization phenomena of thermosenstive moxibustion on knee osteoarthritis patients based on infrared thermography technology

INTERVENTION: Healthy subjects:Use an infrared thermography camera to capture infrared thermal images of the areas to be tested, ensuring the lens angle is adjusted so that the shooting angle does not exceed 45° above or below the vertical direction of the measured surface. The upper and lower boundaries of the thermal image should be based on the position of the label. Instruct the patient to remain quiet, still, and free from distractions during the detection process. The researcher will then use the infrared thermography camera to detect and capture the patient's areas to be measured, taking 1 infrared thermal image of each area. Finally, store the thermal image results in the smartphone of the thermography camera, transfer them to a computer, and use the software provided by the manufacturer's engineer to process the image information. Extract the maximum, minimum, and average temperature values, as well as the image, from the infrared thermal image for each acupoint.;KOA group:Use an infrared thermography camera to capture infrared thermal images of the areas to be tested, ensuring the lens angle is adjusted so that the shooting angle does not exceed 45° above or below the vertical direction of the measured surface. The upper and lower boundaries of the thermal image should be based on the position of the label. Instruct the patient to remain quiet, still, and free from distractions during the detection process. The researcher will then use the infrared thermography camera to detect and capture the patient's areas to be measured, taking 1 infrared thermal image of each area. Finally, store the thermal image results in the smartphone of the thermography camera, transfer them to a computer, and use the software provided by the manufacturer's engineer to process the image infor CONDITION: Knee osteoarthritis PRIMARY OUTCOME: The surface temperature values of acupoints near the knee joint collected by the.; SECONDARY OUTCOME: Western Ontario and McMaster University Osteoarthritis Inde XVisualization Scale (WOMAC) Assessment;Clinical Efficacy Evaluation;Blood, Urine, and Stool Routine Tests, Electrocardiogram, Liver and Kidney Function Tests; INCLUSION CRITERIA: (I) Inclusion Criteria for Knee Osteoarthritis (1) Meets the diagnostic criteria for knee osteoarthritis and K‐L grading criteria at stages I‐III; (2) Meets the diagnostic criteria for knee arthralgia with qi stagnation and blood stasis in traditional Chinese medicine; (3) Patient age between 40‐80 years, no restriction on gender; (4) Informed consent, willing to participate in the trial. The process of obtaining informed consent should comply with GCP regulations. (II) Inclusion Criteria for Healthy Subjects 1. Age between 40‐80 years; 2. No history of knee pain or restricted movement; 3. Routine blood tests, liver and kidney function, ECG, rheumatoid factor, uric acid, and knee X‐ray examination are within normal ranges; 4. Good compliance, willing to cooperate with the study, and sign the informed consent form. Note: Subjects who meet all of the above 4 criteria may be included in this study.