Effect of Licorice in COVID-19

INTERVENTION: Intervention 1: Intervention group: In this group of patients with COVID‐19, in addition to standard treatment introduced by the Ministry of Health, the second drug is also prescribed. It is a licorice‐based herbal extract that contains licorice, Rheum palmatum, Rosa damascene, Crocus sativus, and Ziziphus jujube. In order to prepare this extract, simple substances of these herbal are first prepared from the pharmaceutical market and after identification in the herbarium of the Faculty of Pharmacy of Tehran University of Medical Sciences, a herbarium code is assigned to each one. Then, a herbal syrup is extracted from these herbs by the maceration method. The syrup is standardized based on glycerol content, the total phenolic, and flavonoids compounds by HPLC method. Microbial controls are performed on the syrup. The syrup is packaged in 240 cc dark pets and given to the patient and at a dose of 10 cc every 8 hours for up to 8 days. Intervention 2: Control group: Patients in this group receive only standard treatment provided by the Ministry of Health for COVID‐9. CONDITION: Condition 1: Pneumonia. Condition 2: Acute bronchitis. Condition 3: Acute respiratory distress syndrome (ARDS). ; Other viral pneumonia ; Acute bronchitis due to other specified organisms ; Acute respiratory distress syndrome J12.89 J20.8 PRIMARY OUTCOME: Increase or decrease of respiratory rates more than 25% of primary respiratory rate. Timepoint: Daily. Method of measurement: Respiratory rate in minute. Myocardial Infarction or unstable angina. Timepoint: Daily. Method of measurement: Yes or no. Patient death. Timepoint: Daily. Method of measurement: Yes or no. Patient discharge. Timepoint: Daily. Method of measurement: Yes or no. Rising of creatinine more than 25% primary creatinine. Timepoint: Daily. Method of measurement: milligram in deciliter. INCLUSION CRITERIA: Admitted patients with COVID‐19 in the four hospitals of AJA medical University in Tehran COVID‐19 diagnosed by lung CT or naso‐pharyngeal PCR