An open-label randomized controlled trial of curcumin versus standard dose of omeprazole in treatment of gastroesophageal reflux disease

INTERVENTION: Active Comparator Drug,Active Comparator Drug curcumin ,omeprazole curcumin 500 mg oral four times daily continue for 4 weeks ,omeprazole 20 mg per day oral continue for 4 weeks CONDITION: GERD symptom at entry compare to after 4 weeks of treatment between curcumin and omeprazole ; GERD, curcumin, omeprazole GERD, curcumin, omeprazole PRIMARY OUTCOME: symptom of GERD 4 weeks after treatment number of patient who symptom improve, GSAS SECONDARY OUTCOME: duration of symptom improvement 4 weeks after treatment days INCLUSION CRITERIA: patients who were diagnosed with gastroesophageal reflu Xdisease (GERD) according to the Thailand GERD guideline 2020