Effect of ion channel modification on symptoms in chronic eczema

INTERVENTION: Arm 1: MTRPMC formulation (glycerine cream plus actives) Dose: Apply topically when required for itch/pain associated with eczema Arm 2: Placebo (glycerine cream) Dose: Apply topically when required for itch/pain associated with eczema Each intervention will be given for 13 weeks with a 2 week washout between each arm CONDITION: Dermatologist or allergist diagnosed eczema PRIMARY OUTCOME: PO SCORAD(patient orientated scoring atopic dermatitis) index SCORAD (scoring atopic dermatitis) index SECONDARY OUTCOME: amount of steroid used measured in grams ‐ measurements made by counting number of full tubes of steroid used and adding their weights, plus using measuring scales to weigh any part used tubes to determine weight used. infected eczema and need for antibiotics quality of life reflective itch score; measured using the The Dermatology Life Quality Index (DLQI) reproduced with permission (from Professor Andrew Finlay) http://www.dermatology.org.uk/quality/quality‐life.html INCLUSION CRITERIA: Dermatologist or Allergist diagnosed eczema severity moderate‐severe Significant impairment of quality of life Need for frequent moisturising and topical steroids Must have indicated a willingness to enter the study Must have read and fully understood a study information form Must have had the opportunity to ask any questions prior to enrolment Must have signed study consent form