[Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza A virus].

OBJECTIVE: To construct adenovirus vector vaccine against H5N1 influenza virus and study on the immunogenicity. METHODS: In this study, we amplified hemagglutinin (HA) gene sequence of H5N1 influenza virus (A/Anhui/1/2005), then constructed an adenovirus vector vaccine (Adv-HA), followed by tests in BALB/c mice for the immunogenicity with the vaccine and immunization strategies. RESULTS: The recombinate Adv-HA vaccine could effectively induce both humoral and cellular immunity against human H5N1 influenza virus. CONCLUSION: The Adv-HA vaccination against H5N1 influenza is a potential strategy and worthy of further investigation.