A pilot trial of single versus dual diuretic therapy in the intensive care unit

INTERVENTION: Throughout the patient's admission to the intensive care unit and at the time the treating intensive care doctor has decided to administer an intravenous diuretic, a single intravenous bolus of 40 mg furosemide and 500 mg acetazolamide will be given with the effects monitored via medical record audit. CONDITION: critical care ; ; critical care; Renal and Urogenital ‐ Other renal and urogenital disorders PRIMARY OUTCOME: urinary output after diuretic administration[Total urinary outcome in the 6 hours after diuretic administration while the patient is in the intensive care unit obtained from the medical record.] SECONDARY OUTCOME: Fluid balance effect[Change in fluid balance assessed immediately before and then 6‐hours after diuretic administration while the patient is in the intensive care unit obtained from the medical record.] Serum base excess change[Change in serum base excess level assessed immediately before and then 6‐hours after diuretic administration while the patient is in the intensive care unit obtained from the medical record.] Serum bicarbonate level change[Change in serum bicarbonate level assessed immediately before and then 6‐hours after diuretic administration while the patient is in the intensive care unit obtained from the medical record.] Serum sodium level change[Change in serum sodium level assessed immediately before and then 6‐hours after diuretic administration while the patient is in the intensive care unit obtained from the medical record.] Urinary chloride level change[Change in urinary chloride level assessed immediately before and then 6‐hours after diuretic administration while the patient is in the intensive care unit obtained from the medical record.] INCLUSION CRITERIA: Adults aged 18 years or above Physician decision to administer an intravenous diuretic; Anticipated length of stay of more than 24 hours after intervention administration Existing intra‐arterial or central venous catheter Existing indwelling urinary catheter