Clinical study for xiaoduyuji plaster by traditional Chinese medicine in the treatment of diabetic foot

INTERVENTION: control group:placebo plaster;Treatment group:xiaoduyuji plaster; CONDITION: diabetic foot PRIMARY OUTCOME: Healing rate of skin ulcer;Oxidative stress index; SECONDARY OUTCOME: Apoptosis and proliferation; INCLUSION CRITERIA: (1) diabetes foot (limb gangrene) examination method and diagnostic criteria in line with the American Diabetes Association Diabetes Prevention guideline (2010 Edition) are in line with diagnostic criteria. (2) 40 90 years old; (3) the duration of diabetes mellitus was 5 20 years, and the duration of ulcer (gangrene) was 1 10 years. (4) Wagner classification I III (grade I: there are open lesions on the skin of the extremities. Blisters, blood bubbles, corns, or frostbite, scald are superficial ulcers of the skin caused by other skin operations, but the lesions have not yet affected the deep tissue. Grade II: infected lesions to invade the deep muscle tissue. There are often cellulitis, multiple purulent foci, sinus formation or infection, which expand along the muscle space, resulting in penetrating ulcers on the dorsum of the foot, with more purulent secretions, but the tendons and ligaments have not been damaged. Grade III: muscle Destruction of tendon and li