Ascertaining the role of a nutritional supplement, omega 3 for preventing thinking disability after gynae cancer surgeries

Authors
Category Primary study
Registry of TrialsClinical Trials Registry - India
Year 2026
INTERVENTION: Intervention1: Omega 3 fatty acids‐ Group A: Patients will be asked to consume Omega 3 fatty acid supplementation capsules in the form of Osmega 500,TM one capsule two times a day with meals, providing 325 mg EPA and 175 mg DHA, starting seven days before surgery and continued as one capsule two times a day with meals which will be restarted once the patient is allowed to start orally after surgery (between postoperative day three to five) and continued for 30 days after surgery. The drug dosage and route of administration shall not waver from the current practise and usage guideline. Control Intervention1: Group B‐ Placebo: Patients will receive placebo in the form of empty gelatin capsule, Patco pharma TM one capsule two times a day with meals, starting seven days before surgery and continued as one capsule two times a day with meals which will be restarted once the patient is allowed to start orally after surgery ( usually between postoperative day three to five) and continued for 30 days after surgery. CONDITION: Health Condition 1: C55‐ Malignant neoplasm of uterus, partunspecified PRIMARY OUTCOME: Incidence of POCD at the end one week after surgery using the basic MoCA toolTimepoint: Incidence of POCD at the end one week after surgery using the basic MoCA tool SECONDARY OUTCOME: Incidence of POCD at the end of one month and three months after surgery using the basic MoCA tool ; Total Intraoperative blood loss by various clinical methods ; Number of intraoperative and postoperative hypotensive episodes ; Number of patients requiring intraoperative vasopressor support ; Post operative nausea and vomiting score ; Number of patients requiring rescue analgesics ; Number of patients requiring rescue antiemetics ; Length of hospital stay ; Length of intensive care unit stay ; Quality of life by short form SF 12 questionnaires at baseline at the end of one month and three months after surgery ; Levels of inflammatory markers including CRP and IL 6 at baseline and at the end of one week after surgery ; Timepoint: Incidence of POCD at baseline the end of one month and three months after surgery using the basic MoCA tool Quality of life by short form sf 12 questionnaires at baseline at the end of one month and three months after surgery ; Levels of inflammatory markers including CRP and IL 6 at baseline and at the end of one week after surgery ; INCLUSION CRITERIA: Female patients aged between 50‐75 years, American Society of Anaesthesiologists physical status 1‐2 undergoing elective gynaecological oncology surgeries including carcinoma of ovary, endometrium and cervi Xwithout any preexisting cognitive dysfunction will be included.
Epistemonikos ID: 5dc86a2f3bff2afc5b906b401a8afbc45faba0c9
First added on: Oct 08, 2026