The Impact of Postbiotic Supplementation on Tolerability and Physiological/Metabolic Parameters

This study aimed to evaluate whether daily postbiotic supplementation could improve gastrointestinal well-being and influence physiological and metabolic parameters in healthy young adults. A total of 22 healthy adults participated in this single-center, randomized, placebo-controlled pilot study. Participants were assigned to receive either a daily capsule containing 100 mg of a postbiotic preparation or a placebo for 12 weeks. Gastrointestinal symptoms were assessed using the Gastrointestinal Symptom Rating Scale (GSRS) before and after supplementation. Additional assessments included body composition, metabolic health, intestinal microbiota, inflammation, oxidative stress, and quality of life. The study was designed to explore the potential beneficial effects of postbiotic supplementation on gastrointestinal health and related biological processes.