Effect of dry cupping therapy and galbanum oil in treatment of coronavirus patients

INTERVENTION: Intervention 1: Intervention group: The group which receive cupping therapy with galbanum oil application and standard medicines. Preparation of medicine:To prepare galbanum essential oil, galbanum gum is prepared from a suitable type of reputable herbal market and then, after the approval of a botanist, the voucher number is received from the herbarium of Faculty of Pharmacy, University of Tehran. Then, to prepare its essential oil, 200 g galbanum is poured into a balloon. Then, using water distillation method (hydrodistillation) and Clevenger apparatus, essential oil is extracted for 4 hours and the oil percentage is calculated (V/W). The water residue is removed by anhydrous sodium sulfate and the achieved oil is stored in a dark container in a refrigerator at 4‐5°C prior to use in formulation or in hexane or petroleum ether solvent for essential oil components analysis by GC /MS.The achieved galbanum essential oil was then mixed with Almond violet oil (10%) ( Tuba Green Gold Company) with the ratio of 5:95 and stir to make homogeneous formulation. Intervention 2: Control group: The control group will be received only the prescribed medications for the treatment of COVID‐19 according to the protocol of the Ministry of Health. CONDITION: B34.2 Coronavirus infection. ; Coronavirus infection, unspecified PRIMARY OUTCOME: Percentage of blood oxygen saturation. Timepoint: Before the intervention and days 1,2,3,4,5 after the intervention. Method of measurement: Pulse oximeter device. SECONDARY OUTCOME: Severe need for oxygen therapy. Timepoint: Before the intervention and days 1,2,3,4,5 after the intervention. Method of measurement: CTCAE version 5. Sevierty of Chest pain (non‐cardiac). Timepoint: Before the intervention and days 1,2,3,4,5 after the intervention. Method of measurement: CTCAE version 5. Sevierty of cough. Timepoint: Before the intervention and days 1,2,3,4,5 after the intervention. Method of measurement: CTCAE version 5 (Common Terminology Criteriafor Adverse Events Version 5.0). Sevierty of dyspnea. Timepoint: Before the intervention and days 1,2,3,4,5 after the intervention. Method of measurement: CTCAE version 5. INCLUSION CRITERIA: Positive PCR ?test From 18 to 80 years old (male and female) Clinical criteria for hospitalization (fever = 38 °C‐ sever cough or shortness of breath or blood oxygen saturation= 93% or respiratory Rate =24 breaths/minute or positive CPR Completion of the informed consent form by the patient or his/her companions