The efficacy and tolerability of a moisturizer containing 5% Epigallocatechin-3-Gallate and 2% L-carnitine as adjunctive therapy for acne treatment

INTERVENTION: Active group: Moisturizer containing 5% epigallocatechin gallate (EGCG) and 2% L‐carnitine (LC) with 5% dimethicone and glycerin with topical 0.1% adapalene,Control group: Moisturizer containing 5% dimethicone and glycerin with topical 0.1% adapalene Experimental Drug,Active Comparator Drug Moisturizer containing 5% epigallocatechin gallate (EGCG) and 2% L‐carnitine (LC) with 5% dimethicone and glycerin with topical 0.1% adapalene,Moisturizer containing 5% dimethicone and glycerin with topical 0.1% adapalene CONDITION: acne, skin tolerability, EGCG, L‐carnitine, moisturizer, adapalene Mild‐to‐moderate acne vulgaris patients aged 18‐40 years ; acne, skin tolerability, EGCG, L‐carnitine, moisturizer, adapalene PRIMARY OUTCOME: Global Worst Score (GWS) 8 weeks the arithmetic mean of the maximum (worst) severity across visits for each of the five signs and symptoms (erythema, dryness, burning, pruritus, scaling) SECONDARY OUTCOME: Acne lesion counts 8 weeks acne lesion counts with Leeds revised acne system,Facial sebum 8 weeks Sebumeter,Transepidermal water loss (TEWL) 8 weeks Tewameter,Skin hydration 8 weeks Corneometer INCLUSION CRITERIA: 1. Participants aged 18 to 40 years. 2. Participants diagnosed with mild to moderate acne vulgaris. 3. Participants with Investigator's Global Assessment (IGA) score of 2 or 3. 4. Participants willing to comply with the study protocol and attend all scheduled visits. 5. Participants who provided written informed consent.