Comparison the preventive effects of three different antiseptic agents on creation of phlebitis in peripheral catheter insertion site

INTERVENTION: Disinfect the entry site of peripheral catheters by alcohol Disinfect the entry site of peripheral catheters by chlorhexidine – alcohol Disinfect the entry site of peripheral catheters by povidone ‐ Iodine Intervention 1: Disinfect the entry site of peripheral catheters by alcohol. Intervention 2: Disinfect the entry site of peripheral catheters by povidone ‐ Iodine. Intervention 3: Disinfect the entry site of peripheral catheters by chlorhexidine – alcohol. Prevention CONDITION: Acute reaction to foreign substance accidentally left during a procedure phlebitis and infection of peripheral catheter insertion site following preparation the skin with various anti‐septic agents. ; Acute reaction to foreign substance accidentally left during a procedure PRIMARY OUTCOME: Phlebitis. Timepoint: 48 and 72 hour after chateter insertion. Method of measurement: 0= absence of any clinical symptoms; 1= erythema, with or without pain; 2‐ pain, erythema, edema, or both together; 3‐ pain, erythema, edema, or both together, clear palpable vessel; 4‐ pain, erythema, edema, or both together, clear palpable vessel, and infectious discharge. INCLUSION CRITERIA: INCLUSION CRITERIA: age between 20‐60, need to IV line, conscious patients, exact upper limb. Exclusion criteria: pregnancy, vascular disease, diabetes, severe anemia, headache, glaucoma, high intracranial pressure, hypotension, anticoagulant therapy, corticosteroid therapy.