A randomazied controlled study to evaluate efficacy of low-energy extracorporeal cardiac shock wave therapy in patients with severe coronary artery disease

INTERVENTION: Extracorporeal cardiac shock wave therapy (3 times a week/series, 200 shots/spot at 0.09 mJ/mm2 for 20‐120 spots each time) Placebo treatment (3 times a week/series) CONDITION: Ischemic heart disease PRIMARY OUTCOME: Regional myocardial ischemia.; Evaluated at 3 month after the therapy. SECONDARY OUTCOME: Symptoms (CCS class scores, Frequency in use of nitroglycerin per week), Exercise tolerance.; Evaluated at 3 month after the therapy. INCLUSION CRITERIA: Patients with severe coronary artery disease suffered from stable effort angina with evidence of myocardial ischemia even after adequate medications and with no indication of percutaneous coronary intervention or coronary artery bypass grafting because of diffuse distal coronary artery narrowing.