Diagnostic performance of diffusion and perfusion MRI in differentiating high from low-grade meningiomas: A systematic review and meta-analysis: Diagnostic performance of diffusion and perfusion MRI in differentiating High from low-grade meningiomas: A systematic review and meta-analysis.

OBJECTIVES: The purpose of the present meta-analysis and systematic review was to evaluate the currently published data on the potential role of perfusion (PWI) and diffusion (DWI) weighted imaging for the assessment of meningioma grade. PATIENTS AND METHODS: A search of MEDLINE and relative reference lists was conducted to identify all the eligible studies assessing the diagnostic performance of DWI and PWI in grading meningiomas. Meta-Disc and Rev-Man were used for the statistical analysis. Methodological quality and risk of bias were assessed with the use of the updated Quality assessment of the diagnostic accuracy (QUADAS-2) tool. Pooled sensitivity, specificity and area under the summary receiver operating characteristic curve were calculated individually for DWI and PWI to demonstrate the diagnostic performance of each modality. RESULTS: Fourteen studies with 1063 patients were included. The 8 studies evaluating DWI showed a pooled sensitivity of 80% (95% CI, 74%-86%) and a pooled specificity of 76% (95% CI, 72%-79%). As for the 6 remaining studies concerning PWI, the pooled sensitivity and specificity were found 80% (95% CI, 71%-88%) and 91% (95% CI, 87%-94%), respectively. The area under the SROC curve was 0.94 (95% CI) for PWI and 0.91 (95% CI) for DWI. The comparison of the two AUCs showed that neither technique was superior with regards to the diagnostic performance. CONCLUSIONS: The current evidence proves that both techniques are efficient at differentiating high from low-grade meningiomas.