Effect of Cortisol on Physical Exertion in Patients With Primary Adrenal Failure

The conventional glucocorticoid replacement therapy in primary adrenal insufficiency- Addison\'s disease,renders the cortisol levels unphysiological, which may cause symptoms and long-term complications. Many patients take stress-doses that are extra doses of hydrocortisone or cortisone acetate before or during stressful physical or psychological events. However, the effect of such dosing has not been tested in scientific studies. In this double blind cross-over designed pilot trial we aim to test the effect of an extra dose of cortisol on physical activity and hormone levels.