BCG and Plasma Amyloid in Non-Demented Adults

BCG vaccination, the most widely used vaccination in the world, is used to reduce risk of tuberculosis infection; it is used for other mycobacterial infections as well, benefiting leprosy and Buruli ulcer. BCG has \"heterologous\" effects that aids in an array of non-mycobacterial and viral infections as well as bladder cancer. It is the heterologous effect, sometimes called the \"off-target\" effect that may offer benefit in Alzheimer\'s disease. Population studies and studies of adults receiving BCG show a lessened risk of Alzheimer\'s disease. The study will see if BCG vaccination will alter a plasma test for amyloid, a biomarker for cerebral amyloid.