Sitagliptin and Pioglitazon effects in the treatment of diabetes

INTERVENTION: Intervention 1: tablet sitagliptin 50 to 100 mg and tablet metformin 1000 to 2000 mg daily (for3 month). Intervention 2: tablet pioglitazone 15 to 30 mg and tablet metformin 1000 to 2000 mg daily (for 3 month). tablet pioglitazone 15 to 30 mg and tablet metformin 1000 to 2000 mg daily (for 3 month) tablet sitagliptin 50 to 100 mg and tablet metformin 1000 to 2000 mg daily (for3 month) Treatment ‐ Drugs CONDITION: (E10‐ E11‐ Diabetes mellitus type 2. ; Insulin‐dependent diabetes mellitus ,Non‐insulin‐dependent diabetes mellitus , Malnutrition‐related diabetes mellitus Malnutrition‐related diabetes mellitus , Unspecified diabetes mellitus Insulin‐dependent diabetes mellitus ,Non‐insulin‐dependent diabetes mellitus , Malnutrition‐related diabetes mellitus Malnutrition‐related diabetes mellitus , Unspecified diabetes mellitus PRIMARY OUTCOME: Bs2hpp. Timepoint: Before and three months after intervention. Method of measurement: Elisa. Fasting blood glucose. Timepoint: Before and three months after intervention. Method of measurement: Elisa. HBA1C. Timepoint: Intervention and three months after intervention. Method of measurement: Elisa. SECONDARY OUTCOME: CHOL. Timepoint: Before and three months after intervention. Method of measurement: Elisa. HDL. Timepoint: Before and three months after intervention. Method of measurement: Elisa. TG. Timepoint: Before and three months after intervention. Method of measurement: Elisa. Weight. Timepoint: Intervention and three months after intervention. Method of measurement: Kg using scales. INCLUSION CRITERIA: INCLUSION CRITERIA: Newly diagnosed type 2 diabetic patients In the past year ; HBA1C between 8 to 9.5; BMI between 35‐25; Lack of insulin; written consent to participate in the study criteria ; Exclusion criteria: Liver problems (abnormal level of liver enzymes) (more than 1.5 times the normal); renal failure (BUN and CR abnormal) (creatinine increase greater than1.5); digestive problems (including dyspepsia, diarrhea, vomiting); acidosis (ie, ABG : PH <7/35) heart failure with EF below 35% ; macular edema eye