The ability of body lotion containing provitamin D3 to reduce itching in patients with chronic kidney disease undergoing routine hemodialysis

INTERVENTION: Treatment: body lotion enriched with and without (placebo) provitamin D3 Randomization: simple randomization Details of interventions: 1. 4 g (equal to 20,000 IU provitamin D3) per day, applied to one arm (1.5 g per application) and about 10 cm² area with the most intense itching (0.5 g per application), applied twice daily after bathing, for 28 days 2. Sunbathing twice weekly on the applicated arm CONDITION: Chronic kidney disease‐associated pruritus in patients undergoing routine hemodialysis ; Skin and Connective Tissue Diseases ; Pruritus PRIMARY OUTCOME: Pruritus intensity measured using a 24‐hours Worst Itching Intensity Visual Analog Scale (WI‐VAS) at baseline, 2, and 4 weeks SECONDARY OUTCOME: ; 1. Transepidermal water loss measured using a Tewameter at baseline, 2, and 4 weeks; 2. Stratum corneum hydration measured using a corneometer at baseline, 2, and 4 weeks; 3. Serum calcidiol levels measured using ELISA at baseline and 4 weeks; 4. Serum IL‐31 levels measured using ELISA at baseline and 4 weeks; INCLUSION CRITERIA: 1. 18‐60 years old 2. Complaints of pruritus with WI‐VAS =4 3. Undergoing routine hemodialysis two times a week for =3 months and =10 years 4. Do not use any topical medical treatment for pruritus for at least 2 weeks before the study started. Medical treatment is medicine given by a doctor, both recorded in the Medical Record (MR) of the subject or recorded by the subject 5. Do not use any self‐medication that is topically applied for pruritus for at least 2 weeks before the start of the study. Self‐medication is non‐medical treatment carried out by the subject alone or given by family, including but not limited to herbal concoctions, special soaps, oils, powders, and others 6. Agree to voluntarily participate in the study by signing the informed consent form