Clinical efficacy of Chaihu plus Longgu Oyster soup in the treatment of post-stroke depression and its mechanism based on resting state functional magnetic resonance imaging

Authors
Category Primary study
Registry of TrialsInternational Traditional Medicine Clinical Trial Registry
Year 2026
INTERVENTION: Treatment group:Chai Hu Long Gu Mu Li Decoction combined with Oxalate Escitalopram;Control group:Escitalopram oxalate; CONDITION: post‐stroke depression PRIMARY OUTCOME: HAMD‐17; SECONDARY OUTCOME: Traditional Chinese Medicine Symptom Scale for Post‐Stroke Depression (Hot Depression Shaoyang Type);Hamilton Anxiety Scale;Self‐Rating Depression Scale;National Institute of Health stroke scale;Barthel;Resting‐state functional magnetic resonance imaging;PSQI; INCLUSION CRITERIA: 1) Western medical diagnosis meets the diagnostic criteria for both stroke and depression; 2) Traditional Chinese medicine diagnosis meets the diagnostic criteria for post‐stroke depression; 3) TCM syndrome pattern meets the diagnostic criteria for post‐stroke depression with heat depression and Shaoyang disturbing the mind; 4) HAMD‐17 scale score between 7‐24 indicating mild to moderate depression; 5) Age between 18 and 80 years; 6) Patients receiving Chinese medicine treatment with good compliance; 7) No history of mental illness before onset, and no antidepressant treatment received after onset; 8) Participants or their family members voluntarily participate and sign the informed consent form.
Epistemonikos ID: 58965ddc7c13df1201cfe136b6098d754de0270c
First added on: Aug 10, 2026