Renal protection against ischaemia-reperfusion in transplantation

INTERVENTION: The trial will test whether a simple procedure, the application of a blood pressure cuff to the arm of the donor and the recipient before a kidney transplant, can help protect the donor kidney from the harmful effects of the transplant. The blood pressure cuff to be used is similar to the one that is used to measure blood pressure. It will be inflated continuously for a five‐minute period, after which it will be deflated for 5 minutes. This cycle of inflation, followed by deflation, will be performed 4 times in total. The trial follow up is 5 years, performed in the context of routine clinical follow up. CONDITION: Kidney transplantation ; Injury, Occupational Diseases, Poisoning ; Complications following infusion, transfusion and therapeutic injection PRIMARY OUTCOME: Glomerular filtration rate (GFR) 12 months after transplantation. SECONDARY OUTCOME: 1. Rate of fall in creatinine in the first 72 hours after transplantation; 2. Inflammatory response to surgery in the first 5 days after transplantation; 3. Protein expression in kidney parenchyma samples using histochemistry ; 4. Protein activation and expression in renal vasculature using immunoblotting; 5. Kidney fibrosis 6 months after transplantation; 6. Alloreactivity of T‐cells in the first 18 months after transplantation; 7. Patient outcomes 2 ‐ 5 years after transplantation using renal registry data INCLUSION CRITERIA: 1. Patients undergoing living donor transplantation 2. Patients aged 18 years and above, either sex