Effect of Metformin on Endometrial Thickness in Postmenopausal Breast Cancer Patients Receiving Tamoxifen

Authors
Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2025
The goal of this clinical trial is to learn if metformin can reduce the increase in endometrial thickness caused by tamoxifen in women with estrogen-positive breast cancer taking tamoxifen for more than 1 year. It will also learn about the safety of taking metformin with tamoxifen. The main questions it aims to answer are: 1. Does metformin decrease endometrial thickness in women receiving tamoxifen? 2. What medical problems do participants have when taking metformin with tamoxifen? Researchers will compare tamoxifen plus metformin to tamoxifen plus placebo to see if metformin works to reduce endometrial thickness compared to placebo patients. Participants will: 1. Take metformin daily along with tamoxifen, or take tamoxifen with placebo. 2. Acquire baseline assessment and then visit the clinic at 3 months, 6 months, 9 months and 12 months for checkups and trans abdominal ultrasound test for endometrial thickness, and to be monitored for any side effects or complications.
Epistemonikos ID: 58610fca3ce4b47e2ce115b5311f357df95edc51
First added on: Aug 29, 2025