comparison of Fingolimode and Betaferon(high dose) in M.S treatment

INTERVENTION: Betaferon high dose s.c every 2 days will prescribe 18 months for the other subgroup of patients who had treatment failure during last year with Betaferon (low dose). Fingolimode 0.5 mg /day will orally prescribe 18 months for a subgroup of patients who had treatment failure with Betaferon (low dose) during last year. Intervention 1: Fingolimode 0.5 mg /day will orally prescribe 18 months for a subgroup of patients who had treatment failure with Betaferon (low dose) during last year. Intervention 2: Betaferon high dose s.c every 2 days will prescribe 18 months for the other subgroup of patients who had treatment failure during last year with Betaferon (low dose). Treatment ‐ Drugs CONDITION: M.S. ; Multiple Sclerosis Multiple Sclerosis PRIMARY OUTCOME: Disability Status. Timepoint: befor intervention and 3.9.12.18 months after intervention. Method of measurement: Check list of E.D.S.S. Relapse Numbers. Timepoint: 0,3,9,12,18 months after intervention. Method of measurement: History and observation. INCLUSION CRITERIA: INCLUSION CRITERIA:The most important one is MS patients who had treatment failure (relapsing rate more than one) under Betaferon ( low dose) ; patient acceptance; non immunosuppressive patient. Exclusion criteria: noncooperative patient; death