The Safety and Efficacy of Photodynamic Therapy for Femoral Artery Stenosis

Rstenosis is common after angioplasty of atherosclerotic disease of the femoral artery. Pilot study data suggests that adjuvant photodynamic therapy, using delta amino kleavulinic acid as a photosensitiserr is feasible and safe. This study will examine safety in a larger population and,if recruitment numbers allow, efficacy will be assessed. Hypothesis: ALA photodynamic therapy is safe and well tolerated as an adjuvant to angioplasty as a treatment for femoral artery atherosclerotic stenosis or occlusion. A secondary endpoint will be sought : hypothesis : PDT will reduce in restenosis rates following adjuvant photodynamic therapy compared with standard balloon angioplasty in the treatment of superficial femoral arterial disease.