Systematic Evaluation of Efficacy of Acupuncture in Treatment of Gastroesophageal reflux disease and Meta Analysis

Objective: To explore the clinical efficacy of acupuncture against gastroesophageal reflux disease by conducting a systematic evaluation and meta analysis of acupuncture published in the country and abroad. Method: Computer retrieval Cochrane Library, PubMed, Embase, Chinese Journal Full Text Database (CNKI), VIP), VIP (WANFANG) Relevant randomized controlled trials/semi-randomized controlled trials included from the self-built library to October 2017, quality evaluation and cheap risk assessment of included studies using criteria provided by Cochrane 5.1.0, statistical analysis using Revman 5.3 software. Results: total 26 literature, including 2155 patients (trial group 1087) Example/Control Group Results: (1) Acupuncture combined or non-combined Western medicine for gastroesophageal reflux disease has a higher rate than the western drug group (OR=3.26,95% CI [2.53,4.21], P≈ 0.01); (2) Acupuncture combined or non-combined Western medicine for gastroesophageal reflux disease recurrence rates lower than the western drug group (OR=0.24,95% (OR=95% [0.16,0.36], P ① 0.01); (3) Acupuncture combined or not combined with Western medicine for gastroesophageal reflux disease is better than Western medicine group (SMD=0.62,95% CI [0.41,0.84], P≈ 0.01); (4) Acupuncture combined or not combined with Western medicine alone (SMD = 0.12,95% [- 0.06,0.30], P=0.18 > 0.05); (5) Acupuncture combined or not combined Western medicine outperformed the Western drug group in terms of improvement in patient anxiety status (SMD=1.62,95% CI [1.35,1.89], P≈ 0.01). Conclusion: In terms of total efficacy, recurrence rate, symptom integrals, anxiety status, acupuncture efficacy for sure , the improvement of the subendoscopic mucosa was comparable to the control groups, but due to the overall low quality of the literature, more large samples, multi-center, high-quality randomized clinical controlled trials are still needed to support the results of this study.