Evaluation of the effect of royal jelly on post extraction socket healing

INTERVENTION: Intervention 1: Intervention group: In this group, after tooth extraction and washing the tooth socket with injectable sterile normal saline, pure royal jelly powder (prepared from the pharmaceutical department of Amin Pharmaceutical Co. Isfahan, Iran) which is sterilized through gamma radiation and will be going through Freeze drying process (the inside water will be removed and it becomes a powder); is mixed to a concentration of five percent in sterile normal saline (Sodium Chloride 0.9% for injection, Iranian Parenteral and Pharmaceutical Co. Tehran, Iran). Then the gelatamp smeared with this mixture will be applied on the tooth socket. Intervention 2: Control group: In this group, after tooth extraction and washing the tooth socket with injectable sterile normal saline, gelatamp smeared with sterile normal saline (Sodium Chloride 0.9% for injection, Iranian Parenteral and Pharmaceutical Co. Tehran, Iran) will be applied on the tooth socket. CONDITION: Post extraction socket healing. PRIMARY OUTCOME: Amount of pain. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visual Analogue Scale. Bleeding after palpation of the tooth socket. Timepoint: Examination of bleeding after palpation at the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually. Presence or absence of granulation tissue in the tooth socket. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually. The presence or absence of pus in the tooth socket. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually. Tissue color of the tooth socket. Timepoint: At the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Visually. Wound size of tooth socket. Timepoint: Measurement of wound size at the beginning of the study (immediately after tooth extraction and washing the socket with normal saline) and seven days later. Method of measurement: Using a caliper (ae JUYA instruments, Istanbul, Turkey). INCLUSION CRITERIA: All patients who refer for extraction of non‐impacted molar teeth At least 18 years old Without any systemic disease