Non-infectious skin granulomas in a common variable immunodeficiency

Common variable immunodeficiency is a rare, primary immunodeficiency characterized by hypogammaglobulinemia of IgG and IgA. It classically presents as recurrent respiratory and gastrointestinal infections in young patients, who may also have autoimmune and inflammatory disease, malignancies, malabsorption and non-infectious granulomas, mainly located in the lung, lymph nodes, spleen, liver and, less frequently, in the skin. We report the case of a patient diagnosed with common variable immunodeficiency who presented in the dermatology clinic with multiple, erythematous, crusted nodules on the limbs. Only aseptic granulomas were found.