Tamoxifen in Treatment of Acute Mania

Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2003
Objective: Evidence indicates that the protein kinase C-PKC signaling cascade may be one of the direct targets in treatment of mania. The aim of this study is to investigate whether the PKC inhibitor-tamoxifen has anti-manic properties. Method: Bipolar subjects with manic/mixed episode were randomly assigned to receive either tamoxifen (80mg/day) or identical placebo tablets in 1:1 ratio for three weeks.
Epistemonikos ID: 56a6b8d08cbd525c4f6a40171fc9c3ceb422aab8
First added on: May 04, 2024