Moderate aerobic exercise and Migraine disease

INTERVENTION: Intervention 1: Intervention group: the group of migraine patients who underwent 12 weeks of indoor aerobic exercise training, which lasted three sessions a week for one hour in each session. Intervention 2: Control group: group of migraine patients without exercise training. Intervention 3: Control group: group of healthy people without any disease and without exercise. CONDITION: Migraine. PRIMARY OUTCOME: Matrix metalloproteinases (MMPs) and specific tissue inhibitors of MMPs. Timepoint: 48 hours before and after the training protocol. Method of measurement: blood sampling. INCLUSION CRITERIA: no chronic diseases such as cardiovascular, hypertension, diabetes, arthritis, cancer, asthma, AIDS, meningitis or MS no history of regular exercise in the previous 6 months confirming headache by the neurologist