Effectiveness of extended dose of tranexamic acid for 48 hours vs single dose perioperative tranexamic acid on reduction of blood loss after primary total knee arthroplasty: A randomized controlled trial

INTERVENTION: 3 capsules of 250mg oral tranexamic acid at 8 hours post‐operative and at the interval of 8 hours until 48 hours post‐operative. , 3 capsules of placebo identical to oral tranexamic acid at 8 hours post‐operative and at the interval of 8 hours until 48 hours post‐operative CONDITION: Total knee replacement ; Total knee replacement; Oral tranexamic acid Total knee replacement; Oral tranexamic acid PRIMARY OUTCOME: Total blood loss [Timeframe 72 hour ml] SECONDARY OUTCOME: Blood tranfusion [Timeframe 72 hr unit] Hb level [Timeframe 24 hr , 72 hr g/L] INCLUSION CRITERIA: Patients undergoing primary unilateral total knee arthroplasty Diagnosis of primary osteoarthritis of knee Age less than 85 years old