Prevalence of adverse reactions after dengue vaccinein a young population, in Paraná

Objective: the present study's purpose is to demonstrate the prevalence of dengue vaccine adverse events and its correlation with sociodemographic and clinical characteristics. Material and Methodology: as a cohort study, a questionnaire and phone interviews were applied to the young adults, and data was collected from a database of local services, the Laboratory Environment Manager Abstract of Paraná, and the Dengue Vaccination Control Application. The relation between variables and the presence of vaccine reaction was made via the chi-squared and Fisher exact tests, afterwards, the binary logistic regression method was applied. Results: from 1,815 participants, 6.5% have had some reaction, systemic or local, after receiving the vaccine dose. The most recurrent reactions identified were headaches (59.6%), followed by malaise (32.1%), fever (26.6%), myalgia (22%), local pain (14.6%), considering the last one the only reaction present in three vaccine doses. The first vaccine dose has had a greater chance of reaction comparing to the subsequent doses (p<0.0001). Being female [OR 1.701 (1.144-2.5416), p<0.009] increased the chance of vaccine reaction; however, to have an underlying disease [OR 0.001(0.000-0.002), p=0.000] was a protective factor. Conclusion: the study demonstrated low adverse reactions in the population vaccinated with the dengue vaccine.