Comparison of The prophylactic effect of Zintoma and Ibuprofen in Post-Endodontic pain

INTERVENTION: Ibuprofen group: 0.5 hour before treatment, 1 capsule containing 400 mg ibuprofen is used Intervention 1: Placebo group: 1.5 hour before treatment, 2 placebo capsules are used and 1 hour later, ie 0.5 hour before treatment another 2 placebo capsules are used. Intervention 2: Ibuprofen group: 0.5 hour before treatment, 1 capsule containing 400 mg ibuprofen is used. Intervention 3: Zintoma group: 1.5 hour before treatment two 500 mg zintoma capsules are used and 1 hour later, ie 0.5 hour before treatment another two 500 mg zintoma are used. Placebo Placebo group: 1.5 hour before treatment, 2 placebo capsules are used and 1 hour later, ie 0.5 hour before treatment another 2 placebo capsules are used Treatment ‐ Drugs Zintoma group: 1.5 hour before treatment two 500 mg zintoma capsules are used and 1 hour later, ie 0.5 hour before treatment another two 500 mg zintoma are used CONDITION: Diseases of pulp and periapical tissues. PRIMARY OUTCOME: Pain. Timepoint: before intervention and 4, 8, 12, 24, 48 and 72 hours after intervention. Method of measurement: using VAS registration questionaire. INCLUSION CRITERIA: INCLUSION CRITERIA: 1: Age between 18 and 65 2: No history of the following diseases: mitral valve prolapse, myocardial rheumatism, artificial valve or joint, myocardial infarction, brain stroke, uncontrolled hypertension, hepatitis, seizure, bleeding disorders, peptic ulcer, liver or kidney diseases 3: No history of allergy to NSAIDs or Zingiber Officinale 4: No pregnancy, no breast feeding 5: No other drug consumption at least four hours before study commense 6: Severity of spontaneous pain must be at least five 7: Patients ability to read, comprehend and complete the questionaire and VAS 8; completion of informed consent