A Randomized Controlled Study on the Efficacy of Digital Neuromodulation Software in Improving Cognitive Symptoms of Depression

INTERVENTION: Cognitive Training Group:The intervention group received daily training with a neuromodulation‐based working memory training program in addition to treatment with a single type of SSRI or SNRI antidepressant.;Control group:The control group received systematic treatment with a single type of SSRI or SNRI antidepressant as usual.; CONDITION: Depression PRIMARY OUTCOME: Change in total score of the MATRICS Consensus Cognitive Battery (MCCB) from baseline;Adverse events; SECONDARY OUTCOME: Changes in MCCB dimension scores from baseline at 4 weeks.;Changes in total score and subscale scores of the Perceived Deficits Questionnaire – Depression(PDQ‐D) from baseline;Changes in neural oscillatory EEG data at 4 weeks.;Changes in total score and subscale scores of the Hamilton Depression Rating Scale‐17 items (HAMD‐17) from baseline;Changes in total score and subscale scores of the Hamilton Anxiety Rating Scale (HAMA) from baseline;Changes in total score and subscale scores of the Patient Health Questionnaire – 9 items (PHQ‐9) from baseline;Changes in total score and subscale scores of the 7‐item Generalized Anxiety Disorder Scale (GAD‐7) from baseline;Changes in total score and subscale scores of the Clinical Global Impression Scale (CGI) Test from baseline; INCLUSION CRITERIA: 1.Participants must be aged 12 to 60 years, inclusive, with no gender restrictions. 2.Meeting the diagnostic criteria for Major Depressive Disorder (MDD) according to DSM‐5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition); 3.At the baseline visit, the patient's self‐rated Visual Analogue Scale (VAS) score shows an improvement of >=50% compared to the period of most severe illness. (The VAS consists of a 100 mm line, with one end representing "completely illness‐free" and the other end representing "the most severe illness status"); 4.At least two cognitive domains in the MCCB test have T‐scores below 40; 5.Educational level of elementary school or higher; 6.Voluntary participation in this study, with informed consent signed by the subject themselves, their guardian, or legal representative.