A clinical trial to study the effect of a drug pregabalin in two different doses on preoperative anxiety and postoperative pain in patients undergoing total abdominal hysterectomy

INTERVENTION: Intervention1: Pregabalin: Pregabalin capsule (150 mg) and pregabalin capsule (300mg), two hours before the anesthetic induction Control Intervention1: Placebo: Two placebo capsule, two hours before the anesthetic induction CONDITION: Prevention of Post operative pain in patients undergoing total abdominal hysterectomy PRIMARY OUTCOME: 1. Anxiolysis ; 2. Post operative analgesia ; 3. Opioid sparing effect ; ‐‐‐‐‐‐Timepoint: First 24 hrs in the postoperative period SECONDARY OUTCOME: 1.Reduction in Opioid related adverse effects such as: Respiratory Depression;Nausea and Vomiting;Pruritis;Sedation ; 2.Patient Satisfaction ; ‐‐‐‐‐‐Timepoint: First 24 hrs in the postoperative period INCLUSION CRITERIA: 1. Patients scheduled for TAH 2. Age‐18 to 65 years 3. Ability to operate a patient controlled analgesia (PCA) pump after pre surgery instructions