Effects of mometazone furoate hydrate on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen

INTERVENTION: Mometazone furoate hydrate is administrated intranasally at a dose of 200microgram to the subjects for 4 days and then the artificial exposure of Japanese cedar pollen at the concentration of 8000 counts/m3. CONDITION: allergic rhinitis PRIMARY OUTCOME: The expression of histamine H1 receptor and allergy‐related cytokine mRNA in the nasal mucosa SECONDARY OUTCOME: The allergic rhinitis symptoms including sneezing, nasal discharge and nasal obstruction INCLUSION CRITERIA: Adult patients with allergic rhinitis to cedar pollen