The effects of different opioids on emergence from general anesthesia for short gynecological surgery

Authors
Category Primary study
Registry of TrialsISRCTN registry
Year 2016
INTERVENTION: Participants are randomly allocated to one of two groups by computer. Group 1: Patients are given 0.02 mg/kg midazolam (Dormicum) IV, in addition to IV 1 mcg/kg remifentanil (Ultiva) administered over thirty seconds. Participants are then given 2 mg/kg propofol (Pofol) for anesthesia induction. Additional dosing can be given if required according to the bispectral index guidance (0.3 mg / kg propofol and 0.2 mcg /kg Remifentanil) during the procedure. Group 2: Patients are given 0.02 mg/kg midazolam (Dormicum) IV, in addition to IV 1 mcg/kg fentanyl (Fentanyl) administered over thirty seconds. Participants are then given 2 mg/kg propofol (Pofol) for anesthesia induction. Additional dosing can be given if required according to the bispectral index guidance (0.3 mg / kg propofol and 0.2 mcg /kg fentanyl) during the procedure. Participants in both groups are then observed in the post‐anesthesia care unit in order to determine emergence time from general anesthesia. CONDITION: General anesthesia in gynecological prcedures ; Pregnancy and Childbirth ; General anesthesia in gynecological prcedures PRIMARY OUTCOME: 1. Emergence time from general anesthesia is determined by recording time taken for the patient to open their eyes and provide a verbal answer to a question; 2. Discharge time from post‐anesthesia care unit is determined according to modified Aldrete score at the time of discharge from the post‐anesthesia care unit SECONDARY OUTCOME: 1. Pain is measured using the visual analog scale post‐operatively in the post‐anesthesia care unit; 2. Additional analgesic requirement (if VAS is upper 5 point) post‐operatively in the post‐anesthesia care unit; 3. Patient satisfaction with anesthesia is measured using the visual analogue scale post‐operatively in the post‐anesthesia care unit; 4. Intra‐operative dreaming is measured through patient interviews 10 minutes post‐operatively INCLUSION CRITERIA: 1. Female patients between 18 and 60 years 2. ASA physical status I‐II 3. Have undergone dilatation curettage and/or endometrial biopsy procedures
Epistemonikos ID: 50e4733a809bf295049fd32905942b7c0ccc2e37
First added on: Aug 24, 2024