Effect of probiotics and yoga practice on metabolic syndrome in menopausal women

INTERVENTION: This is a randomized controlled clinical study with four arms. Thirty women aged 40 to 65 with metabolic syndrome will be selected and randomly assigned into four groups: Group 1 (Probiotics): Administration of capsules containing probiotics (20000 IU of Lactobacillus helveticus R0052, Bifidobacterium longum R0175, and Bifidobacterium bifidum), once a day in the morning. Group 2 (Yoga): Shivam Yoga classes, twice a week, each lasting 60 minutes. Group 3 (Yoga + Probiotics): Shivam Yoga classes twice a week, each lasting 60 minutes + administration of capsules containing probiotics (20000 IU of Lactobacillus helveticus R0052, Bifidobacterium longum R0175, and Bifidobacterium bifidum), once a day in the morning. Group 4 (Control): Administration of capsules containing placebo (lactose), once a day in the morning. CONDITION: C18.452 metabolic syndrome PRIMARY OUTCOME: It is expected to observe a significant reduction (p<0.005) in the frequency of metabolic syndrome after the use of probiotics and/or yoga practices. SECONDARY OUTCOME: It is expected to find a significant reduction (p<0.005) in anthropometric parameters (weight, waist circumference, and body fat percentage) after the use of probiotics and/or yoga practices It is expected to observe a significant improvement (p<0.05) in laboratory parameters (glucose, glycated hemoglobin, insulin, uric acid, and lipid profile) after the use of probiotics and/or yoga practices To identify changes in microRNAs, circular RNAs, and long‐chain RNAs after the use of probiotics and/or yoga practices INCLUSION CRITERIA: Climacteric women; age between 40 to 65; diagnosis of metabolic syndrome according to the Joint Interim Statement (JIS) criteria