The prednisolone prescription effect on post CABG surgery inflammatory mediators

INTERVENTION: In control group 15mg/Kg Prednisolone bolus dose before operation and after sedation will be prescribed. After operation this group will be had steady infusion of normal saline (2mg/Kg/d) Intervention 1: In control group 15mg/Kg Prednisolone bolus dose before operation and after sedation will be prescribed. After operation this group will be had steady infusion of normal saline (2mg/Kg/d). Intervention 2: Intervention group will be prescribed 1mg/Kg dose of prednisolone (bolous dose) before operation and 2mg/Kg/d as infusion after that. Intervention group will be prescribed 1mg/Kg dose of prednisolone (bolous dose) before operation and 2mg/Kg/d as infusion after that. Placebo Treatment ‐ Drugs CONDITION: coronary artery disease. ; Ischaemic heart diseases I20‐I25 Ischaemic heart diseases PRIMARY OUTCOME: Length of stay in ICU and Intubation time. Timepoint: after transferring the patient to surgery ward. Method of measurement: questionnaire. SECONDARY OUTCOME: Reduction of inflammatory mediators. Timepoint: before, 6 and 48 hours following operation. Method of measurement: Blood test. INCLUSION CRITERIA: INCLUSION CRITERIA:1‐ age over 18. 2‐ written informed consent. 3‐ patients who are candidate for open heart surgery. Exclusion criteria: 1‐ recent use of systemic corticosteroid. 2‐ history of bacterial or fungal infection in the past two weeks. 3‐ history of sensitivity to corticosteroids. 4‐ uncontrolled diabetes mellitus. 5‐ history of renal failure 6‐ liver failure or elevated liver enzymes.