27479 Does caffeine has positive effect on the prevalence of nonmelanoma skin cancer? Case-control study in Korea

Background: Nonmelanoma skin cancer (NMSC) is one of the most common cancer worldwide, and has also accounted for thousands of cases a year in Korea, and the number is increasing. Dietary factors such as coffee have drawn attention as a possible effective factor in NMSC research, but few studies have been conducted on Asians. Objective: We explored the association between coffee intake and prevalence of NMSC in a hospital-based case-control study. Methods: Enrolled participants are 141 cases and 181 controls of two hospitals in Korea. Coffee intake was assessed using a validated food frequency questionnaire which included the average amount of coffee a day and type of coffee consumed in the last year. Logistic regression was used to estimate the relative risk of NMSC as odds ratios (ORs) with 95% confidence intervals (CI). Results: We found that increase of each cup in daily coffee consumption was significantly associated with decrease in risk of NMSC by 18%. Compared with women with 0 cup/day, significantly increased OR (3.98, 95% CI = 1.21-13.08, P =.02) was shown in women with ≥1 cup/day of instant coffee with sugar and cream, whereas there was decreased OR (0.15, 95% CI = 0.03-0.68, P =.02) in women with ≥1 cup/day of black coffee. However, significant associations were not observed among men. Conclusion: This study supports the evidence that coffee intake, especially black coffee intake is associated with the decreased risk of NMSC in Korean women.