How does dietary carbohydrate influence the formation of an atherogenic lipoprotein phenotype?

INTERVENTION: The study will be a randomised, dietary intervention with a cross‐over design. It will examine the effect of two test diets for 12 weeks, that differ in the quality of carbohydrate (high and low non‐milk extrinsic sugars [NMES]), in two groups of subjects at risk of metabolic syndrome but with different proportions of liver fat (low liver fat less than 2% and moderate liver fat greater than 10% but less than 20%). The test diets will be preceded by a 4‐week run‐in diet and separated by 4 weeks of wash‐out. CONDITION: Topic: Diabetes Research Network, Primary Care Research Network for England; Subtopic: Other; Disease: Cardiovascular disease ; Nutritional, Metabolic, Endocrine ; Dietary carbohydrate PRIMARY OUTCOME: Formation of high‐ and low‐risk lipoprotein phenotypes SECONDARY OUTCOME: 1. LDL kinetics, with a focus on the formation of small dense LDL; 2. Sources of liver fat; 3. Whether VLDL‐TG is derived from increased DNL and/or systemically derived NEFA; 4. VLDL kinetics, with focus on differential effects on the synthesis of VLDL‐TG and VLDL‐apoB INCLUSION CRITERIA: Not provided at time of registration