The Effect of Losartan and Amlodipine on Left Ventricular Diastolic Function in Patients With Mild-to-Moderate Hypertension

INTERVENTION: treatment with angiotensin II type 1 receptor blocker treatment with calcium channel blocker CONDITION: Hypertensive heart disease PRIMARY OUTCOME: LV diastolic function SECONDARY OUTCOME: carotid artery atherosclerosis; BNP; PIIIP; CITP; high sensitivity C‐reactive protein INCLUSION CRITERIA: •Mild to moderate hypertension (systolic blood pressure with 140 mmHg or over and with 200 mmHg or less, diastolic blood pressure with 90 mmHg or over and with 110 mmHg or less, •Presence of LV hypertrophy (a ratio of LV mass to body surface area (LV mass index) with 120 g/m2 or over in men and with 105 g/m2 or over in women, or LV wall thickness > 11 mm. •LV diastolic dysfunction (a ratio of peak early to late diastolic filling velocities (E/A) < 1.0 or > 1.5, an E‐wave deceleration time <160 msec or >280 msec, isovolumic relaxation time <60 msec or > 105 msec) •LV ejection fraction with 50% or over