Comparison of the Success of Centbucridine and lignocine Local Anesthetic Injections for Painless Root Canal Treatment of Lower Back Teeth.

Authors
Category Primary study
Registry of TrialsClinical Trials Registry - India
Year 2026
INTERVENTION: Intervention1: 0.5 percent Centbucridine: Centoblock, 30 ml Vial, Local Anesthetic agent, Themis Medicare Limited. Control Intervention1: 2 percent Lignocaine: Themicaine AD, 1:200000, 30 mL Vail, Local anesthetic agent, Themis Medicare Limited. CONDITION: Health Condition 1: K040‐ Pulpitis PRIMARY OUTCOME: successful inferior alveolar nerve block enabling painless access opening and root canal treatment without the need for supplemental anesthesiaTimepoint: 15 Minutes SECONDARY OUTCOME: Intraoperative pain assessment using Heft‐Parker visual analogue scale.Timepoint: 45 minute Onset of anesthesia evaluated subjectively by checking for lip/tongue numbness after 4 minutes and objectively for pulpal aesthesia by EPT and cold test after 15 minutes.Timepoint: 15 mnutes INCLUSION CRITERIA: ASA I or II Patients, Mandibular first molar diagnosed with asymptomatic irreversible pulpitis, positive response to electric pulp test, moderate to severe preoperative pain, tooth indicated for nonsurgical root canal treatment, restorable tooth, willing to provide consent
Epistemonikos ID: 4d42b3ff11bc0d2cf56885606538f4cec5b8bcf3
First added on: Oct 08, 2026