Investigating the effect of resveratrol on polycystic ovary syndrome

Authors
Category Primary study
Registry of TrialsIranian Registry of Clinical Trials
Year 2023
INTERVENTION: Intervention group: use of resveratrol. In this group of patients, for 60 days until puncture, they take two capsules of 800 mg of resveratrol daily, twice in the morning and in the evening. Their routine treatment, including metformin, is not stopped.. CONDITION: E28.2 Polycystic ovary syndrome. ; Polycystic ovary syndrome PRIMARY OUTCOME: Analysis mtDNA. Timepoint: Sixty days after taking the medicine. Method of measurement: PCR. Analysis of SIRT1 protein expression. Timepoint: Sixty days after taking the medicine. Method of measurement: Western Blot. Examining NRF1 gene expression. Timepoint: Sixty days after taking the medicine. Method of measurement: real time PCR. Examining pgc1 gene expression. Timepoint: Sixty days after taking the medicine. Method of measurement: real time PCR. Examining TFAM gene expression. Timepoint: Sixty days after taking the medicine. Method of measurement: real time PCR. Examining UCP2 gene expression. Timepoint: Sixty days after taking the medicine. Method of measurement: real time PCR. Investigating the function and biosynthesis of mitochondria. Timepoint: Sixty days after taking the medicine. Method of measurement: real time PCR, western blot. Investigation of mitochondrial membrane potential. Timepoint: Sixty days after taking the medicine. Method of measurement: JC1 staining. SECONDARY OUTCOME: Number and quality of embryos. Timepoint: 60 days after the start of the intervention. Method of measurement: Counting, optical microscopy. The number and quality of oocytes. Timepoint: 60 days after the start of the intervention. Method of measurement: Counting, optical microscopy. INCLUSION CRITERIA: Diagnosis of Polycystic ovary syndrome (PCOS) based on Rotterdam criteria Polycystic ovary syndrome (PCOS) patients who are candidates for ART
Epistemonikos ID: 4d2f71692f5c3cdaa106cc72fdda5f8120849829
First added on: Feb 20, 2024