A double-center, prospective, randomized controlled trial to evaluate the efficacy, safety, and satisfaction of different injection methods using ART FILLER UNIVERSAL for correcting moderate to severe nasolabial folds in Chinese adults

INTERVENTION: A:The left side was injected with the traditional deep and shallow layer method, while the right side was injected with the ligament method;B:The right side was injected with the traditional deep and shallow layer method, while the left side was injected with the ligament method; CONDITION: Nasolabial fold PRIMARY OUTCOME: Wrinkle Severity Rating Scale;Global Aesthetic Improvement Scale; INCLUSION CRITERIA: 1. Subjects older than or equal to 18 years old; 2. Patients who intend to correct bilateral nasolabial fold were evaluated as moderate to severe nasolabial fold (WSRs grade 2‐3); 3. Subjects who voluntarily participated in the study and signed informed consent; 4. The subjects who can communicate well with the researchers and comply with the requirements of the whole trial can return to the hospital for reexamination on the follow‐up date.