Yohimbine premedication and 35% CO2 vulnerability in healthy volunteers.

Authors
Category Primary study
JournalEuropean archives of psychiatry and clinical neuroscience
Year 1994
A group of 20 healthy volunteers underwent a 35% carbon dioxide/65% oxygen air-placebo controlled challenge test twice, premedicated 1 h before with either 20 mg yohimbine or placebo, following a double-blind randomized crossover design. Contrary to expectation the anxiety response to carbon dioxide was not higher when premedicated with yohimbine compared to premedication with placebo. Possible implications of this finding are discussed, with reference to general chemical models of panic.
Epistemonikos ID: 4c23ca76a2de5a3ffa27a3c3eb58c9448da8c0e2
First added on: May 14, 2022