Application of Large Language Models Techniques to Post-ICU Syndrome Management in Critically Ill Patients: A Fully Longitudinal Mixed Study

Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2025
The goal of this clinical trial is to evaluate whether Large Language Models (LLMs) combined with an optimized care program can effectively manage Post-Intensive Care Syndrome (PICS) in adult ICU survivors (aged ≥18 years) discharged from a tertiary hospital in China. The main questions it aims to answer are: * Does the intervention (optimized program + LLMs) improve physical, psychological, cognitive, and social function recovery compared to standard care or the optimized program alone? * How do patients experience and perceive the utility of LLMs in PICS self-management during recovery? Researchers will compare three groups: 1. Group A (routine care) 2. Group B (optimized program without LLMs) 3. Group C (optimized program + LLMs) to see if adding LLMs significantly enhances PICS symptom management, patient self-efficacy, and quality of life over 6 months post-discharge. Participants will: * Install and use the Kimi Smart Assistant LLM (Group C only) for health queries under nurse supervision. * Complete standardized questionnaires at discharge (baseline), 7 days, 1 month, 3 months, and 6 months post-discharge: * PICS Symptom Questionnaire (PICSQ) * Pittsburgh Sleep Quality Index (PSQI) * Anxiety (GAD-7) and Depression (PHQ-9) scales * Self-Management Ability Scale (AHSMSRS) * Attend semi-structured interviews (Group C only) at 3 and 6 months to share experiences with LLM use.
Epistemonikos ID: 4b508c7de89c3d06572fca84b9217e7d19f6eeab
First added on: Aug 27, 2025