Use of dexamethasone and clomiphene citrate in patients with polycystic ovarian syndrome resistant to clomiphene citrate

INTERVENTION: Group 2: Clomiphene Citrate, 100 mg, was given from 3rd day until 7th day plus folic acid tab from 3rd day until 12th day Group I: Clomiphene Citrate, 100 mg, was given from 3rd day until 7th day plus dexamethasone 2mg/day orally in two divided doses Intervention 1: Group I: Clomiphene Citrate, 100 mg, was given from 3rd day until 7th day plus dexamethasone 2mg/day orally in two divided doses. Intervention 2: Group 2: Clomiphene Citrate, 100 mg, was given from 3rd day until 7th day plus folic acid tab from 3rd day until 12th day. Placebo Treatment ‐ Drugs CONDITION: Polycystic ovarian syndrome Polycystic ovarian syndrome. ; Polycystic ovarian syndrome PRIMARY OUTCOME: Ovulation. Timepoint: 36‐48 hr after HCG injection. Method of measurement: fluid in the cul‐de‐sac or corpus luteum formation, disappearance of pre‐ovulatory follicle. Pregnancy. Timepoint: 25 days after HCG administration. Method of measurement: transvaginal ultrasound examination. SECONDARY OUTCOME: Number of matured follicles. Timepoint: 12‐18 days after first of menstuaration. Method of measurement: sonography. INCLUSION CRITERIA: INCLUSION CRITERIA: having PCOS according to the Rotterdam criteria for diagnosis of PCOS, age between 18 and 35 years, period of infertility >1/5 years and normal DHEAS levels. Exclusion criteria: hyperprolactinaemia, hypercorticism or thyroidism, pelvic pathology or surgery, infertility factor other than anovulation.